RAD 140: Side Effects, Dosage & Results

Aug 19, 2023

RAD 140 is a Selective Androgen Receptor (SARM) that is commonly known as Testolone. It is gaining popularity in the bodybuilding sphere due to its ability to increase muscle mass, power, and fat loss. In this article, we will be taking an in-depth look at what RAD 140 is, what benefits it offers, any side effects it may cause, and how to cycle and stack it.

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RAD 140 was first discovered by Miller et al. in 2011 [1]. It was tested in animal studies from 2013, and the first human study was initiated in October 2017, where the effects of RAD 140 on postmenopausal women with breast cancer were studied [2].

RAD 140 was developed by Radius Health and then licensed to Ellipses Pharmaceuticals in 2020. It has been sold for several years now and has a large number of followers. This is because it is believed to be a safer and more effective alternative to anabolic steroids.

RAD 140 is a selective androgen receptor (SARM). SARMS work in a similar way to anabolic steroids by binding to androgen receptors and simulating male sex hormones. Where SARMS differ from anabolic steroids is that they target specific cells, while anabolic steroids target many cells in the body.

Because of this, SARMS tend to have much fewer side effects than anabolic steroids and can also be used more strategically. SARMs are also 100% legal to purchase for research purposes.

RAD 140 can be sold as liquid, powdered form or in capsules. There is a newer version of RAD 140, which is known as RAD 150. This version has been esterified, which theoretically increases bioavailability and makes it more potent. Many people prefer RAD 140, though, as they believe that it is safer, due to its effects being more established in research and anecdotally.

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Unlike traditional sports supplements such as creatine monohydrate, or even illegal supplements such as anabolic steroids, SARMS have a very small number of human studies on them. This makes it hard to definitively list all the benefits that RAD 140 (and other SARMS) can offer.

Many of the benefits listed below have some scientific research backing them, but there is also a lot of anecdotal evidence (perhaps field research would be a fairer description?) from the thousands of amateur bodybuilders and regular gym goers who have used them.

Benefit #1 RAD 140 Increases Your Metabolic RateWe know that RAD 140 binds to androgen receptors and simulates the effects of increased testosterone. This, in turn, leads to a significant increase in your metabolism, helping your body to burn more calories during the day. This can be used to create a large calorie deficit, and it is why so many users report excellent fat loss results after use.

If you are looking to burn fat, then RAD 140 is a great way to do so. In this manner, it is very similar to anabolic steroids, which can cause fat loss without you even having to exercise (though exercise and diet will, of course, massively improve your results).

As mentioned earlier, there are limited human studies into the effects of SARMS. However, a 2007 study on rats found that SARMS led to decreased body fat as well as improved body composition [3].

SARMS can also help you to train at a higher intensity, build muscle, and have more energy during the day. All of these can increase your metabolism.

Benefit #2 RAD 140 Increases Muscle MassThere are three ways in which SARMS, such as RAD 140, can help you to increase your muscle mass. The first is by increasing muscle protein synthesis. A 2019 study found that rats who took SARMS saw increases in muscle protein synthesis, allowing their muscles to grow larger [4].

SARMS may also have anti-catabolic effects, meaning that you can train for longer and at a higher intensity without your muscles becoming overworked and beginning to lose size.

The third way in which RAD 140 can increase muscle mass is by aiding in your sleep and recovery time. This ties into muscle protein synthesis, but it also reduces the amount of rest and recovery that is required between sessions, allowing you to train more often.

Benefit #3 RAD 140 Improves Recovery from ExerciseThis benefit was mentioned in the previous benefit, but it really deserves its own spot. Not only can improved recovery lead to bigger and stronger muscles, but it can also help to reduce your risk of injuries. Whether SARMS can prevent or treat injuries is debated strongly in bodybuilding forums and Reddit, with both sides making a good case.

As SARMS such as RAD 140 can help you to recover faster, then your risk of injury will be lowered. However, they also allow you to train harder and at an increased intensity, which raises your risk of injury. Perhaps the two cancel each other out, but there are certainly a lot of bodybuilders who claim to be injury-free due to their use of SARMS.

Benefit #4 RAD 140 Increases AthleticismThere is a good reason why WADA has banned SARMS from the sports it oversees, and it is for that same reason that so many athletes have been caught using SARMS. The UFC, in particular, appears to have a SARMS culture, with numerous athletes being caught using them. Of all the SARMS found to be used, RAD 140, Ligandrol, and Ostarine appear to be the most popular [5].

This is because RAD 140 is great at increasing muscle mass and, therefore, power while also helping with improved recovery and potential injury risk reduction (see above), and it can also help with fat burning, which is crucial for sports which require you to make a certain weight (possibly why it is so popular with UFC fighters).

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RAD 140 Side EffectsAs with the benefits of RAD 140, it is a little hard to properly study the side effects when there are so few human studies, particularly long-term studies. That does not mean that we can’t identify some common side effects that are either mentioned by frequent users, or found in the literature.

One of the most commonly reported side effects of SARMS is liver toxicity, with a 2020 medical case study discussing a 52-year-old man who took RAD 140 and suffered from Jaundice [6]. However, it should also be noted that the man was a recreational drug user and regularly drank beer and whiskey.

We find that people who have taken RAD 140 commonly report elevated liver enzyme counts, but they also state that after the cycle had finished, their liver enzyme number returned to normal. Of course, with repeated cycles, this may become more of an issue.

The best practice would be to avoid RAD 140 if you have had liver-related health issues in the past.

Other side effects that have been mentioned include insomnia, water retention, and raised blood pressure. That does not mean that these are the only side effects that can occur, nor does it mean that they are all caused by RAD 140. That’s the issue with such an under-researched supplement.

RAD 140 DosageRAD 140 capsules are 10 mg, and while there is no evidence-based dosage advice, the most common dosage for men is between 10 mg and 20 mg per day. Smaller men (and most women) should probably take lower dosages, while large men (bodybuilders, for example) often take higher dosages than 20 mg per day.

RAD 140 CycleAgain, there is no evidence-based answer to this, just anecdotal evidence from the many bodybuilders who use RAD 140. We see typical cycles lasting six to eight weeks. Though many people state that six weeks is the golden period and that results tend to dry up between six and eight weeks.

Others follow longer cycles but tend to start with smaller dosages and build their way up to 10-20 mg per day. This ends up with the same 6-8 week cycle, just with a few weeks of slowly building tolerance and getting used to RAD 140.

RAD 140 PCTPCT stands for Post-Cycle Therapy. PCT is commonly performed after an anabolic steroid cycle as the body has stopped producing testosterone levels, and it can take a while to naturally return to regular testosterone production.

PCT involves drugs such as Clomid, which lowers estrogen levels and increases luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This helps to stimulate increased testosterone production in the body, returning your testosterone production level to normal and helping you to avoid the symptoms of low testosterone.

Whether you need PCT after taking RAD 140 is debatable at the moment. Many people claim that this is only the case if you use poor-quality sources of RAD 140. However, it does make sense to get your blood tested after a cycle. If your testosterone production has been impaired, then Clomid or similar PCT options may be beneficial.

RAD 140 Results: What to ExpectIt is common for users to gain 10-15lbs of lean muscle on RAD 140. However, it really is all about the effort that you put in. Thus, if someone is training hard and disciplined with their diet, they will experience maximum results. In contrast to someone who misses workouts, dosages and is sloppy with their diet.

Typical muscle increases for someone on RAD 140 will be around 1kg of muscle per week. The longer they have been on RAD 140, the less they will gain from each consequent cycle.

This amount of weight gain doesn’t sound like much until you realise that it is solid muscle tissue and makes a dramatic impact when looking in the mirror.

Should You Take RAD 140 in the Morning or at Night?The truth is that it doesn’t really matter from a results point of view. Whether you prefer the morning or the night is going to differ from person to person. Some people find that taking it late at night can cause them some insomnia, but many people don’t notice this at all.

Some people find that taking it early in the morning can cause them to feel nauseated, but many people don’t notice this at all. You get the idea. There is no right answer here. Try one way. If you don’t like it, try the other.

RAD 140 StacksThere is a lot of discussion about what stacks best with RAD 140, but the truth is that for most people, there is no need to try and stack RAD 140 with other SARMS (as a beginner).

Only once a person builds tolerance to RAD 140 should they think of stacking it, with potentially MK-677, Ostarine or LGD-4033.

We also see Cardarine being mentioned as a good stack with RAD 140 for fat burning, while LGD is recommended for lean muscle building, and MK-677 for overall thickness/mass.

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RAD 140 PriceThe price of RAD 140 differs depending on which company you use, which country you live in, and whether you can get yourself a discount or not. The average price in the US appears to be $70-80 for a reputable company, but once shipping has been added, the price can rise even higher. In the UK, the price ranges from £35-70, but this encompasses a wide range of standards.

Ostarine vs RAD 140Ostarine is an easier SARM to start off with and is often seen as an allrounder, while RAD 140 is a little harder to get started with and tends to focus more on bulking. Though it can also be used for fat burning if you adjust your diet and exercise for that. We find that RAD 140 has more reported side effects and is also more likely to require a PCT afterwards. But it is better at building muscle.

RAD 140 vs RAD 150Both RAD 140 and RAD 150 are more powerful than Ostarine, but both suffer from greater side effects. RAD 150 is said to provide slightly better results but with slightly worse side effects. Minor hair loss being a common complaint.

LGD-4033 vs RAD 140Ligandrol (LGD-4033) appears to be better for building muscle, while RAD 140 is better for fat loss and for general energy levels. The side effects for both appear to be similar. Ligandrol is a lot cheaper than RAD 140, which may be something to consider.

Testol 140 is a herbal supplement that attempts to live off the reputation of RAD 140. It describes itself as a legal and natural alternative to Testolone. But it won’t really provide you with any of the benefits of RAD 140.

Offering mild natural testosterone support, a reduction in cortisol, and an improvement in mood. But no increases in muscle mass or improvements in body composition. It really is a bit of a marketing ploy. Easy for new lifters to confuse the two, which is the only reason why this supplement exists.

RAD 140 is a well-known SARM that is known to work in bodybuilding circles. In clinical research we see it building muscle, gaining weight, and even with fat burning. The side effects are not as bad as some of the more aggressive SARMS out there, but you may need to consider PCT afterwards. RAD 140 is one of the most stable and popular SARMS out there, and it has a superb reputation.

References[1] https://pubs.acs.org/doi/10.1021/ml1002508

[2] https://cancerres.aacrjournals.org/content/80/4_Supplement/P5-11-01

[3] https://pubmed.ncbi.nlm.nih.gov/17063395/

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348734/

[5] https://bmmagazine.co.uk/business/numerous-sports-athletes-turning-to-sarms-for-performance-enhancement/

[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535764/

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